Séminaire de Pavel Ivanov, Harvard Medical School, USA

à 10h45,  Amphithéâtre Becquerel, Ecole Polytechnique  

RNA G-quadruplexes and cellular stress
 

RNA G-quadruplexes (rG4s) are non-canonical secondary structures formed by guanine-rich sequences that are found in different regions of RNA molecules. These structures have been implicated in diverse biological processes, including translation, splicing, and RNA stability. Recent studies have suggested that rG4s play a role in the cellular response to stress. I will discuss functions of tetramolecular rG4s derived from transfer RNAs, and roles of rG4 transcriptome in gene regulation during stress adaptation.

Short biography:
I am trained in Moscow, Berlin, Heidelberg and Boston in the area of RNA biology. I am currently anAs sociate Professor of Medicine at BWH and HMS, and an Associate Member of the Broad Institute of Harvard and M.I.T., and Associate Member of Harvard Institute of RNA medicine. My laboratory’s research interests are RNA granules, translational control, non-coding RNAs (both small and long ncRNAs) and RNA G-quadruplexes.

Contact :    Jean-Louis Mergny

                   jean-louis.mergny at polytechnique.edu