Defects in DNA repair genes drive the emergence of antimicrobial resistance in Mycobacterium tuberculosis

The growing problem of antibiotic resistance worsens the social and economic burden of tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb). Using large-scale genomic analyses and genome editing, a LOB team has identified associations between defects in DNA repair system genes and the development of drug resistance in Mtb. This study underlines the need for genomic surveillance to anticipate the emergence of antimicrobial resistance in this high-priority pathogen (WHO 2024).

Nature 2025 (npj Antimicrobials and Resistance)