Résultats de la recherche
2299 résultats
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Naoimagerie de la signalisation cellulaire
Oxidative signalingReactive Oxygen Species (or ROS), such as H2O2, play a major in numerous patho-physiolgical process, notably in the triggering and evolution of complex patholgoies, such as some cancers or (auto)-inflammation related diseases. Their quantitative monitoring in cells and tissues is…
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Actualité - Labo LOB
New Prize
A big congratulations to Kate Sorg, third prize IP Paris My Thesis in 180 SecondsShe will take part in the regional final of the MT 180 competition, which will take place on April 16, 2026, at La Terrasse in Gif-sur-Yvette. 2026 WinnersThe jury, composed of prominent figures from the acad…
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Actualité - Labo LOB
New publication in Nature Communication Biology, “Label-free nonlinear microscopy probes cellular metabolism and myelin dynamics in live tissue”
A new paper on “Label-free nonlinear microscopy probes cellular metabolism and myelin dynamics in live tissue” is published in Communications Biology, thanks to an exciting collaboration between the Laboratoire d'Optique et Biosciences (LOB) at Institut Polytechnique de Paris and the Institut du Ce…
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Actualité - Labo LOB
New publication in npj Heritage Science, first paper from the LOB on OCT applied to the investigation of cultural heritage artifacts.
Congratulation to Gael Latour's team. First paper from the LOB on OCT applied to the investigation of cultural heritage artifacts. We show the interest in imaging varnish layers, measuring their thicknesses and following conservation treatments based on varnish removing. An interdisciplinary work b…
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Actualité - Labo LOB
New publication in Nucleic Acids Research ”Archaeal G-quadruplexes: a novel model for understanding unusual DNA/RNA structures across the tree of life"
Happy to share latest article on G-quadruplexes in Archaea: "Archaeal G-quadruplexes: a novel model for understanding unusual DNA/RNA structures across the tree of life" published in Nucleic Acids Research Link in comments (paper in free access).We introduce Haloferax volcanii as a tractable archae…
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Actualité - Labo LOB
New publication in Optica - Two-photon light-sheet live imaging at kilohertz frame rate using birefringence-based pulse splitting
A new paper from the LOB microscopy unit on high-speed multiphoton light-sheet imaging has been published in Optica. We achieved kilohertz frame rates by enhancing the signal-to-photodamage ratio during live imaging.Two-photon light-sheet live imaging at kilohertz frame rate using birefringence-bas…
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Nicolas David
Research director - CNRSRoom: 84-20-24Phone: (+33) 1 69 33 50 88nicolas.david at polytechnique.eduCurrent research activityCell migration and morphogenesis in the early embryo PublicationsScholar • orcid:0000-0003-1166-6732 PhD theses advised or co-advised- Yara Hassanein (with S.Escot, i…
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Nonlinear polarimetry
Polarization-resolved multiphoton microscopy (nonlinear polarimetry) provides submicron information on organized samples.We develop P-SHG to probe collagen macromolecular organization, and P-THG to probe ordered lipids and biominerals.Related publicationsMultiscale characterization of myelin distri…
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Actualité - Labo LOB
Opération Coquelicots au LOB #coquelicots #IWD2025
Le LOB soutient avec enthousiasme l'opération coquelicots et se pare de rouge pour rendre visibles les femmes scientifiques!
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Pascale Changenet
Coordinator of the "Internal dynamics of biomolecules" research groupSenior researcher - CNRSPièce : 02-2015Tél : 01 69 33 50 30pascale.changenet-barret@polytechnique.edu Research interestsLight-induced processes in complex molecular systemsTime-resolved circular dichroism Femtoseco…
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PhD & Master internships
PhD and Master internship proposals are generally advertized between October and March. For inquiries about the current possibilities, you can also contact LOB scientists.Master/PhD proposals 2026:Brain-wide mapping with color multiphoton microscopy [see project page] (E. Beaurepaire, P. Mahou)Char…
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